TRIBOLOGICAL PROPERTIES AND PHYSIOCHEMICAL ANALYSIS OF POLYMER-CERAMIC COMPOSITE COATINGS FOR BONE REGENERATION

Tribological Properties and Physiochemical Analysis of Polymer-Ceramic Composite Coatings for Bone Regeneration

The biomaterial coatings for bone tissue regeneration described in this study promote bioactivity.The ceramic-polymer composite coatings deposited on polylactide (PLA) plates contain polymers, namely polyvinylpyrrolidone (PVP)/polyethylene glycol (PEG), while the ceramic phase is hydroxyapatite (HA).Additionally, collagen (COL) and glutathione Extr

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Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials

Abstract The extensive heterogeneity and the limited availability of effective targeted therapies contribute to the challenging prognosis and restricted survival observed in GRAHAM CRUMBS triple-negative breast cancer (TNBC).Recent research indicates the aberrant expression of diverse tyrosine kinases (TKs) within this cancer, contributing signific

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Brucein D, a Naturally Occurring Tetracyclic Triterpene Quassinoid, Induces Apoptosis in Pancreatic Cancer through ROS-Associated PI3K/Akt Signaling Pathway

Brucein D (BD), a major active quassinoid in Brucea javanica, has exhibited pronounced anticancer activities.However, the biologic mechanisms have not been fully explored.In this study, BD exhibited more potent cytotoxic effect on pancreatic cancer (PanCa) cell lines, while exerted weaker cytotoxic effects on GES-1 cells (non-tumorigenic).BD was sh

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